Abstract Views :140 |
PDF Views:0
Authors
Affiliations
1 School of Studies in Chemistry, Jiwaji University, Gwalior-474011, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 523-525
Abstract
Phosphoramidates (N-P) are biologically active organic compounds because they are capable of inhibiting enzyme action. A few members of this class were synthesized and checked for their anticholinesterase properties and they were found to be a good reactive phosphorylating agent to block AChE rather than BuChE in the poisoning process. The presence of chloro-substituent (either ortho- or para-) in the aryl moiety of these phosphoramidates does not show any significant contribution during toxicological study made in vitro. These phosphoramidates were characterized by FTIR, 31P NMR and GC-MS spectral studies.
Keywords
Phosphorylation, Phosphoramidates, Anticholinesterase, 31P NMR, Toxicity.
